HIV-1/copyright induced oxidative stress disrupts tight junction protein-1 in human pulmonary microvascular endothelial cells: role of Ras/ERK1/2 pathway.

Intravenous drug use (IVDU) is the major risk factor in the development of HIV-related pulmonary Gold arterial hypertension (HRPAH); however, the pathogenesis of HRPAH in association with IVDU has yet to be characterized.Endothelial injury is considered to be an initiating factor for pulmonary vascular remodeling in animal models of PAH.Our previou

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